the target for human monoclonal antibodies…

Discovery in 2008 of the target for human monoclonal antibodies highly conserved among one group of yearly returning and some pandemic influenza viruses (Throsby, PLOS One, 2008). This target was subsequently defined by co-crystallography of the antibody- antigen complex (Ekiert, Science, 2009). Antibodies binding this conserved target on the influenza virus protected against the disease when given before infection as well as after (Koudstaal, J Infect Dis,2009; Friesen, PloS One 2010). First in man studies will be initiated with the lead candidate antibody in 2011.

Publications:

THROSBY, M., BRINK, E. van den, JONGENEELEN, M., POON, L.L., ALARD, P., CORNELISSEN, L., BAKKER, A., COX, F., DEVENTER, E.V., GUAN, Y., CINATL, J., MEULEN, J. ter, LASTERS, I., CARSETTI, R., PEIRIS, M., KRUIF, J. de,
and GOUDSMIT, J. (2008)
Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM Memory B Cells.
PLoS ONE 3 (12): e3942.
PubMed publication date: Dec 16, 2008.
PubMed link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/19079604
PDF: PLoS ONE_2008_3_12_e3942_Throsby

EKIERT, D.C., BHABHA, G., ELSLIGER, M.A., FRIESEN, R.H., JONGENEELEN, M., THROSBY, M., GOUDSMIT, J., and WILSON, I.A. (2009)
Antibody recognition of a highly conserved influenza virus epitope.
Science 324 (5924): 246-251.
PubMed publication date: Apr 10, 2009.
PubMed link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/19251591
PDF: Science_2009_324_5924_246_Ekiert
PDF Supplementary Materials: Science_2009_324_5924_246_Ekiert_SOM

KOUDSTAAL, W., KOLDIJK, M.H., BRAKENHOFF, J.P., CORNELISSEN, L.A., WEVERLING, G.J., FRIESEN, R.H., and GOUDSMIT, J. (2009)
Pre- and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir.
J Infect Dis 200 (12): 1870-1873.
PubMed publication date: Dec 15, 2009.
PubMed link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/19911992
PDF: J Infect Dis_2009_200_12_1870_Koudstaal

FRIESEN, R.H., KOUDSTAAL, W., KOLDIJK, M.H., WEVERLING, G.J.,
BRAKENHOFF, J.P., LENTING, P.J., STITTELAAR, K.J., OSTERHAUS, A.D.,
KOMPIER, R., and GOUDSMIT, J. (2010)
New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets.
PLoS One 5 (2): e9106.
PubMed publication date: Feb 8, 2010.
PubMed link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/20161706
PDF: PLoS One_2010_5_2_e9106_Friesen

December 2008
Discoveries