The target for the second most important group of influenza viruses

Discovery in 2011 of the target of the second most important group of influenza viruses. On August 12, 2011 Science published our report “A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses”. The crystal structure of this new antibody with the 1968 pandemic H3 strain revealed a highly conserved epitope in the HA stalk distinct from in 2008 found H1 and H5 antibodies. This discovery opened the way to create a cocktail of antibodies to fight influenza A and opened the way towards a universal influenza vaccine.

Publication:

EKIERT, D.C., FRIESEN, R.H., BHABHA, G., KWAKS, T., JONGENEELEN, M., YU, W., OPHORST, C., COX, F., KORSE, H.J., BRANDENBURG, B., VOGELS, R.,
BRAKENHOFF, J.P., KOMPIER, R., KOLDIJK, M.H., CORNELISSEN, L.A., POON, L.L., PEIRIS, M., KOUDSTAAL, W., WILSON, I.A., and GOUDSMIT, J. (2011)
A highly conserved neutralizing epitope on group 2 influenza A viruses.
Science 333 (6044): 843-850.
PubMed publication date: Aug 12, 2011.
PubMed link to abstract: http://www.ncbi.nlm.nih.gov/pubmed/21737702

August 2011
Discoveries