Discovery in 2004 of a prototype AIDS vaccine based on a common cold virus as carrier (so-called Ad 35 ) (J Immunol, 2004, Barouch), the final Ad35 based vaccine being discovered in 2006 (Havenga, J Gen Virol, 2006). Subsequently two new strategies were tried out, one using the combination of Ad5 and Ad48 in one vaccine construct ( Ad5HVR48, Nature, Roberts, 2006; Barouch J Virol, 2009) and one using Ad26 (Abbink, J Virol, 2007; Lui Liu, J Virol, 2008). Finally proof was obtained for protection against AIDS by combining two distinct cold viruses, one given after the other (Lui Liu, Nature, 2009). In 2010 the combination of Ad35 and Ad 26 was tested in humans and in 2011/2012 the first trial in humans will be done of a ‘true’ Ad35/Ad26 vaccine aimed at protection against HIV and AIDS.
Publications:
BAROUCH, D.H., PAU, M.G., CUSTERS, J.H., KOUDSTAAL, W., KOSTENSE, S., HAVENGA, M.J., TRUITT, D.M., SUMIDA, S.M., KISHKO, M.G., ARTHUR, J.C., KORIOTH-SCHMITZ, B., NEWBERG, M.H., GORGONE, D.A., LIFTON, M.A.,
PANICALI, D.L., NABEL, G.J., LETVIN, N.L., and GOUDSMIT, J. (2004)
Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity.
J Immunol 172 (10): 6290-6297.
PubMed publication date: May 15, 2004
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/15128818
PDF: J Immunol_2004_172_10_6290_Barouch
HAVENGA, M., VOGELS, R., ZUIJDGEEST, D., RADOSEVIC, K., MUELLER, S., SIEUWERTS, M., WEICHOLD, F., DAMEN, I., KASPERS, J., LEMCKERT, A., MEERENDONK, M.V., VLUGT, R.V.D., HOLTERMAN, L., HONE, D., SKEIKY, Y., MINTARDJO, R., GILLISSEN, G., BAROUCH, D., SADOFF, J.,
and GOUDSMIT, J. (2006)
Novel replication-incompetent adenoviral B-group vectors: high vector stability and yield in PER.C6© cells.
J Gen Virol 87 (Pt 8): 2135-2143.
PubMed publication date: Aug, 2006.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/16847108
PDF: J Gen Virol_2006_87_8_2135_Havenga
ROBERTS, D.M., NANDA, A., HAVENGA, M.J., ABBINK, P., LYNCH, D.M.,
EWALD, B.A., LIU, J., THORNER, A.R., SWANSON, P.E., GORGONE, D.A.,
LIFTON, M.A., LEMCKERT, A.A., HOLTERMAN, L., CHEN, B., DILRAJ, A.,
CARVILLE, A., MANSFIELD, K.G., GOUDSMIT, J., and BAROUCH, D.H. (2006)
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity.
Nature 441 (7090): 239-243.
PubMed publication date: May 11, 2006.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/16625206
PDF: Nature_2006_441_7090_239_Roberts
Continuation of AIDS Vaccine Publications:
BAROUCH, D.H., LIU, J., LYNCH, D.M., O’BRIEN, K.L., LA PORTE, A., SIMMONS, N.L., RIGGS, A.M., CLARK, S., ABBINK, P., MONTEFIORI, D.C., LANDUCCI, G.,
FORTHAL, D.N., SELF, S.G., CARVILLE, A., MANSFIELD, K.,
and GOUDSMIT, J. (2009)
Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys.
J Virol 83 (18): 9584-9590.
PubMed publication date: Sep, 2009.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/19553307
PDF: J Virol_2009_83_18_9584_Barouch
ABBINK, P., LEMCKERT, A.A., EWALD, B.A., LYNCH, D.M., DENHOLTZ, M., SMITS, S., HOLTERMAN, L., DAMEN, I., VOGELS, R., THORNER, A.R., O’BRIEN K, L.,
CARVILLE, A., MANSFIELD, K.G., GOUDSMIT, J., HAVENGA, M.J.,
and BAROUCH, D.H. (2007)
Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D.
J Virol 81 (9): 4654-4663.
PubMed publication date: May, 2007.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/17329340
PDF: J Virol_2007_81_9_4654_Abbink
LIU, J., EWALD, B.A., LYNCH, D.M., DENHOLTZ, M., ABBINK, P., LEMCKERT, A.A., CARVILLE, A., MANSFIELD, K.G., HAVENGA, M.J., GOUDSMIT, J.,
and BAROUCH, D.H. (2008)
Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys.
J Virol 82 (10): 4844-4852.
PubMed publication date: May, 2008.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/18337575
PDF: J Virol_2008_82_10_4844_Liu
LIU, J., O’BRIEN, K.L., LYNCH, D.M., SIMMONS, N.L., LA PORTE, A., RIGGS, A.M., ABBINK, P., COFFEY, R.T., GRANDPRE, L.E., SEAMAN, M.S., LANDUCCI, G., FORTHAL, D.N., MONTEFIORI, D.C., CARVILLE, A., MANSFIELD, K.G.,
HAVENGA, M.J., PAU, M.G., GOUDSMIT, J., and BAROUCH, D.H. (2009)
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.
Nature 457 (7225): 87-91.
PubMed publication date: Jan 1, 2009.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/18997770
PDF: Nature_2009_457_7225_87_Liu