Discovery in 2005 of a mixture of two human monoclonal antibodies made by recombinant DNA technology against rabies to replace the short in supply
anti-rabies antiserum recovered from human or horse blood. (Bakker, J Virol, 2005). In 2006 we were able to show that our mixture was as good in protecting against rabies as the old remedy (Goudsmit, JID, 2006). In 2008 we were able to show that the two human monoclonal antibodies retained activity in humans for weeks and were, when given in a fixed mixture, completely harmless (Bakker,Vaccine, 2008). Trials in Asia are planned to show efficacy in humans in 2011-2013.
BAKKER, A.B., MARISSEN, W.E., KRAMER, R.A., RICE, A.B., WELDON, W.C., NIEZGODA, M., HANLON, C.A., THIJSSE, S., BACKUS, H.H., KRUIF, J. de, DIETZSCHOLD, B., RUPPRECHT, C.E., and GOUDSMIT, J. (2005)
Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants.
J Virol 79 (14): 9062-9068.
PubMed publication date: Jul, 2005.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/15994800
PDF: J Virol_2005_79_14_9062_Bakker
GOUDSMIT, J., MARISSEN, W.E., WELDON, W.C., NIEZGODA, M., HANLON, C.A., RICE, A.B., KRUIF, J. de, DIETZSCHOLD, B., BAKKER, A.B.,
and RUPPRECHT, C.E. (2006)
Comparison of an anti-rabies human monoclonal antibody combination with human polyclonal anti-rabies immune globulin.
J Infect Dis 193 (6): 796-801.
PubMed publication date: Mar 15, 2006.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/16479514
PDF: J Infect Dis_2006_193_6_796_Goudsmit
BAKKER, A.B., PYTHON, C., KISSLING, C.J., PANDYA, P., MARISSEN, W.E.,
BRINK, M.F., LAGERWERF, F., WORST, S., CORVEN, E. van, KOSTENSE, S., HARTMANN, K., WEVERLING, G.J., UYTDEHAAG, F., HERZOG, C., BRIGGS, D.J., RUPPRECHT, C.E., GRIMALDI, R., and GOUDSMIT, J. (2008)
First administration to humans of a monoclonal antibody cocktail against rabies virus: Safety, tolerability, and neutralizing activity.
Vaccine 26 (47): 5922-5927.
PubMed publication date: Nov 5, 2008.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/18804136