Discovery in 2006 of a prototype malaria vaccine based on a common cold virus (Ad35) as carrier for malaria protein (Ophorst, Infect Immun, 2006).
Next in 2007 we were able to show that our Ad35 vaccine against human malaria improved the malaria protein vaccine, called RTS,S of GSK (Stewart, Infect Immun, 2007). In 2009 we proved for malaria the concept that two heterologous common cold viruses carrying malaria proteins and administered consecutively, boost the immune response against malaria substantially (Rodriguez, Vaccine, 2009). On top of that protective responses against a protein malaria were shown to be boosted by the combination of our Ad35/Ad26 malaria vaccine. (Radosevic, Clin Vaccine Immunol, 2010) .Challenge studies in humans are predicted to start in 2011.
Publications:
OPHORST, O.J., RADOSEVIC, K., HAVENGA, M.J., PAU, M.G., HOLTERMAN, L., BERKHOUT, B., GOUDSMIT, J., and TSUJI, M. (2006)
Immunogenicity and protection of a recombinant human adenovirus
serotype 35-based malaria vaccine against Plasmodium yoelii in mice.
Infect Immun 74 (1): 313-320.
PubMed publication date: Jan, 2006.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/16368986
PDF: Clin Vaccine Immunol_2010_17_11_1687_Radosevic
STEWART, V.A., MCGRATH, S.M., DUBOIS, P.M., PAU, M.G., METTENS, P., SHOTT, J., COBB, M., BURGE, J.R., LARSON, D., WARE, L.A., DEMOITIE, M.A.,
WEVERLING, G.J., BAYAT, B., CUSTERS, J.H., DUBOIS, M.C., COHEN, J.,
GOUDSMIT, J., and HEPPNER, D.G., JR. (2007)
Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone.
Infect Immun 75 (5): 2283-2290.
PubMed publication date: May, 2007.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/17307942
PDF: Infect Immun_2007_75_5_2283_Stewart
RODRIGUEZ, A., MINTARDJO, R., TAX, D., GILLISSEN, G., CUSTERS, J., PAU, M.G., KLAP, J., SANTRA, S., BALACHANDRAN, H., LETVIN, N.L., GOUDSMIT, J.,
and RADOSEVIC, K. (2009)
Evaluation of a prime-boost vaccine schedule with distinct adenovirus vectors against malaria in rhesus monkeys.
Vaccine 27 (44): 6226-6233.
PubMed publication date: Oct 19, 2009.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/19686691
PDF: Vaccine_2009_27_44_6226_Rodriguez
RADOSEVIC, K., RODRIGUEZ, A., LEMCKERT, A.A., MEER, M.V.D., GILLISSEN, G., WARNAR, C., EYBEN, R.V., PAU, M.G., and GOUDSMIT, J. (2010)
The Th1 immune response to Plasmodium falciparum circumsporozoite protein is boosted by adenovirus vectors 35 and 26 with a homologous insert.
Clin Vaccine Immunol 17 (11): 1687-1694.
PubMed publication date: Nov, 2010.
PubMed link to abstract: https://www.ncbi.nlm.nih.gov/pubmed/20826614
PDF: Vaccine_2009_27_44_6226_Rodriguez