Discovery in 2006 of a prototype malaria vaccine based on a common cold virus (Ad35) as carrier for malaria protein (Ophorst, Infect Immun, 2006). Next in 2007 we were able to show that our Ad35 vaccine against human malaria improved…
Discovery in 2005 of a mixture of two human monoclonal antibodies made by recombinant DNA technology against rabies to replace the short in supply anti-rabies antiserum recovered from human or horse blood. (Bakker, J Virol, 2005). In 2006 we were…
Discovery in 2004 of a prototype AIDS vaccine based on a common cold virus as carrier (so-called Ad 35 ) (J Immunol, 2004, Barouch), the final Ad35 based vaccine being discovered in 2006 (Havenga, J Gen Virol, 2006). Subsequently two…
Discovery in 1989 that the presence of HIV in the fluid surrounding the brain (cerebrospinal fluid) is directly related to the presence of symptoms of dementia like loss of memory and attention. Simultaneously it was found that treatment with zidovudine…
Discovery in 1988 that antibodies blocking HIV infection target a highly variable part of the outside of the AIDS virus (the so-called V3 loop) indicating that making an AIDS vaccine will not be easy (PNAS, 1988). In 1992 we showed…
